Comparison of the Efficacy of Letrozole and Clomiphene Citrate in women having Anovulatory Infertility
نویسندگان
چکیده
Aim: To compare the efficacy of letrozole and clomiphene citrate in women having anovulatory infertility. Study design: Randomized Controlled Trial. Place duration study: 16th October 2020 to 15th September 2021 Department Obstetrics & Gynecology, Shahida Islam Medical Complex Lodhran. Methods: In our study 112 patients between ages 18 40 years with anovulation were included. Patients H/O previous pelvic surgery, raised prolactin TSH levels excluded. These divided into02 groups i.e. Group A (clomiphene citrate) B (letrozole), by lottery method effectiveness was noted both groups. Results: Mean age group 24.53±6.12 25.37±6.33 years. Majority included study, 78(69.64%) 30 Duration infertility 3.28±2.11 3.63±2.10 3.79±2.14 The drug shownin 9(8.03%) while 18(16.07%) (p-value = 0.005). Conclusion: We concluded from this that is proved be more efficacious than Keywords: Anovulation, Infertility, Letrozole, Clomiphene Citrate, Conception Rate
منابع مشابه
Letrozole versus Clomiphene Citrate in Patients with Anovulatory Infertility
Objective: To compare the effectiveness of letrozole and clomiphene citrate (CC) in patients with anovulatory infertility. Design: Open, prospective, randomized, parallel group, multicentric, comparative trial. Setting: Outpatient clinics of infertility centers in India. Patient(s): Fifty-five patients with anovulatory infertility were recruited. Twenty-seven patients (59 cycles) were given let...
متن کاملLetrozole or clomiphene citrate as first line for anovulatory infertility: a debate
Clomiphene citrate has been traditionally used as the drug of choice in treating women with anovulatory infertility. In the last decade letrozole, an aromatase inhibitor has emerged as alternative ovulation induction agent. Literature confirms that letrozole has a definitive role in anovulatory women who have not responded to the clomiphene therapy. However its role as an alternative to clomiph...
متن کاملClomiphene for anovulatory infertility.
Evidence • Systematic review of RCTs of antiestrogens in PCOS1: -In 3 RCTs (N = 133) that examined clomiphene (50 to 250 mg/d, 1 to 5 cycles) versus placebo, the pregnancy rate was higher with clomiphene (20% vs 3%); the number needed to treat (NNT) was 6. Live births and miscarriages were not reported. -Limitations: small sample, variable dosing and number of cycles, high dropout rate, poor ad...
متن کاملLaparoscopic Ovarian Drilling for Polycystic Ovarian Syndrome in Clomiphene Citrate-Resistant Women with Anovulatory Infertility
Results: Follow-up data, which were available for 181 patients, showed a spontaneous ovulation rate of 70.1%, cumulative ovulation rate of 98.3%, and pregnancy rate of 84.5%. Women who conceived following surgery were obese, had higher pre-operative luteinizing hormone (LH) levels, were younger and were more likely to have typical ultrasonographic features of polycystic ovarian disease. Logisti...
متن کاملComparison of the use of letrozole and clomiphene citrate in regularly ovulating women undergoing intrauterine insemination
Objective: To compare the effects of letrozole 5mg and clomiphene citrate (CC) 100mg on total follicle number, endometrial thickness, hormone levels, pregnancy, miscarriage and OHSS rate in women undergoing superovulation and I.U.I. Material and methods: This study was done as a prospective randomized trial in Research and Clinical Center for Infertility (Shahid Sadoughi University) and Mother ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pakistan Journal of Medical and Health Sciences
سال: 2023
ISSN: ['1996-7195']
DOI: https://doi.org/10.53350/pjmhs202317233